There is a general lack of recommendations for and basic information tailored at sexologists and other health-care professionals for when they encounter trans people in their practice. The present position statement aim to fill this gap by proposing a series of recommendation, formulated by a team of experts belonging to the European Society of Sexual Medicine: the topic of sexual health and well-being is particularly stressed, mostly in relation to the possible effects of hormonal treatment. The Authors highlight that evidence is limited, due to rapidly changing field.